Task 1 Chromosomes, genes and DNA
Design a labelled/annotated diagram titled ‘What are genes?’ It should:
§ show where chromosomes, genes and DNA are found
§ be labelled with a description of each component
§ identify the relationship between all three components.
If you complete this task correctly, you will meet grading criterion P1.
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Task 2 Evolving because of genetic variation
Sickle cell syndrome is a common disease in people who come from areas of
People who have one copy of the sickle cell gene do not get ill with sickle cell syndrome, but their red blood cells are slightly abnormal. The malaria parasite can not use these abnormal red blood cells to grow. Therefore, people who carry the sickle cell disease are less likely to die of malaria.
§ How is sickle cell syndrome inherited?
§ What is the genetic probability of two carriers of sickle cell syndrome having a child who is:
§ also a carrier
§ has sickle cell syndrome.
§ Explain why sickle cell syndrome is so high in regions where there is a risk of catching malaria. In your explanation you should use these words:
§ Variation in genes doesn’t just bring about evolutionary change in humans and it isn’t always associated with disease. Describe another example in nature where genetic variation led to evolutionary change.
If you complete this task correctly, you will meet grading criterion M1.
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Task 3 The genetic code and variation
Genes are comprised of four different bases combined in a unique way.
§ Draw a diagram to illustrate the four bases and how they bond together in DNA.
§ What role does the genetic code play in variation?
§ What types of mistakes (mutations) in the genetic code can lead to genetic diseases?
§ The most common cause of sickle cell anaemia is an A to T mutation in the sickle cell gene. Explain in simple terms what this means.
If you complete this task correctly, you will meet grading criterion D1
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